Title : Methadone binding to orosomucoid (alpha 1-acid glycoprotein): determinant of free fraction in plasma.

Pub. Date : 1981 Feb

PMID : 7193106






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Percentage dl-methadone bound to purified human serum albumin (HSA) (4.1 mg/dl) was 36.60% (mean +/- SD). Methadone albumin Homo sapiens
2 Addition of alpha 1-AGP (0.05 to 2.0 gm/l) to a physiologic concentration of purified HSA or to whole plasma progressively increased methadone binding. Methadone albumin Homo sapiens