Title : Primaquine-mediated oxidative metabolism in the human red cell. Lack of dependence on oxyhemoglobin, H2O2 formation, or glutathione turnover.

Pub. Date : 1982 Jul 15

PMID : 7126253






4 Functional Relationships(s)
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1 Stimulation of the hexose monophosphate shunt by primaquine does not primarily involve H2O2 accumulation since stimulation of the pathway by primaquine was also observed in red cells containing methemoglobin, a red cell preparation in which no H2O2 accumulates. Primaquine hemoglobin subunit gamma 2 Homo sapiens
2 Methemoglobin prevented the formation and/or accumulation of H2O2 in intact red cells incubated with primaquine as well as in a non-cellular system containing primaquine plus Fe2+-EDTA as an H2O2 source. Primaquine hemoglobin subunit gamma 2 Homo sapiens
3 Methemoglobin prevented the formation and/or accumulation of H2O2 in intact red cells incubated with primaquine as well as in a non-cellular system containing primaquine plus Fe2+-EDTA as an H2O2 source. Primaquine hemoglobin subunit gamma 2 Homo sapiens
4 In the red cell, primaquine stimulated glucose-dependent conversion of methemoglobin to oxyhemoglobin. Primaquine hemoglobin subunit gamma 2 Homo sapiens