Pub. Date : 1982 Feb
PMID : 7057390
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Buprenorphine effects on plasma luteinizing hormone and prolactin in male heroin addicts. | Buprenorphine | prolactin | Homo sapiens |
| 2 | Buprenorphine, a mixed opiate agonist-antagonist, suppressed plasma luteinizing hormone (LH) and increased prolactin levels after 12 consecutive days of ascending dose administration (0.5-8 mg/day s.c.) in comparison to drug-free control conditions. | Buprenorphine | prolactin | Homo sapiens |
| 3 | During a subsequent 10-day period of buprenorphine maintenance at a dose of a 8 mg s.c., LH levels remained suppressed and prolactin levels continued to be elevated. | Buprenorphine | prolactin | Homo sapiens |
| 4 | Tolerance to buprenorphine effects on LH and prolactin levels did not occur during chronic drug administration. | Buprenorphine | prolactin | Homo sapiens |
| 5 | Buprenorphine-induced changes in plasma LH and prolactin after chronic administration to human males were smaller than those observed with less potent opiate agonist drugs. | Buprenorphine | prolactin | Homo sapiens |
| 6 | Effects of buprenorphine on LH and prolactin levels are more consistent with the actions of opiate agonists rather than opiate antagonists. | Buprenorphine | prolactin | Homo sapiens |