Title : Human lung tissue and anaphylaxis. I. The role of cyclic GMP as a modulator of the immunologically induced secretory process.

Pub. Date : 1977 Sep

PMID : 70437






3 Functional Relationships(s)
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1 A close relationship between increased concentrations of cyclic GMP in human lung tissue and the capacity for acetylcholine to enhance the immunologic secretion of histamine and SRS-A has been found. Acetylcholine 5'-nucleotidase, cytosolic II Homo sapiens
2 Acetylcholine (10(-7) to 10(-11) M) produced parallel increases in both cyclic GMP and the immunologic release of mediators; the muscarinic blocking agent atropine prevented both responses. Acetylcholine 5'-nucleotidase, cytosolic II Homo sapiens
3 The increase in cyclic GMP in human lung after acetylcholine stimulation was apparent within 30 sec, peaked by 120 sec, and abruptly returned to control levels thereafter. Acetylcholine 5'-nucleotidase, cytosolic II Homo sapiens