Title : Influence of microsomal and cytosolic fractions from rat, mouse, and hamster liver on the mutagenicity of dimethylnitrosamine in the Salmonella plate incorporation assay.

Pub. Date : 1981 Nov

PMID : 7030474






4 Functional Relationships(s)
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1 Dimethylnitrosamine (DMN) was mutagenic in the Salmonella plate incorporation assay (Ames test) at a level of 10 mumol/plate (3.7 mM) in the presence of hamster liver S-9. Dimethylnitrosamine proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 Mus musculus
2 Dimethylnitrosamine (DMN) was mutagenic in the Salmonella plate incorporation assay (Ames test) at a level of 10 mumol/plate (3.7 mM) in the presence of hamster liver S-9. Dimethylnitrosamine proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 Mus musculus
3 Mutagenicity of DMN at this level was not observed when the S-9 was derived from mouse or rat liver, although the mouse liver and hamster liver S-9 had similar DMN demethylase activities. Dimethylnitrosamine proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 Mus musculus
4 The presence of an inhibitor of DMN activation in rat and mouse microsomes may account for, or contribute to, the failure of liver S-9 preparations from these species to activate DMN to a mutagen under standard conditions of the Ames test. Dimethylnitrosamine proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 Mus musculus