Title : In vitro inhibition of alcohol dehydrogenase by acrylamide: interaction with enzyme-SH groups.

Pub. Date : 1981 Mar

PMID : 7018024






4 Functional Relationships(s)
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1 In vitro inhibition of alcohol dehydrogenase by acrylamide: interaction with enzyme-SH groups. Acrylamide aldo-keto reductase family 1 member A1 Homo sapiens
2 Acrylamide, a reactive electrophile, caused a concentration-dependent inhibition of alcohol dehydrogenase (ADH) activity (purified) which was reversed by prior addition of glutathione. Acrylamide aldo-keto reductase family 1 member A1 Homo sapiens
3 Acrylamide, a reactive electrophile, caused a concentration-dependent inhibition of alcohol dehydrogenase (ADH) activity (purified) which was reversed by prior addition of glutathione. Acrylamide aldo-keto reductase family 1 member A1 Homo sapiens
4 The results demonstrate that acrylamide-induced inhibition of purified ADH activity is mediated through its specific interaction with -SH groups in the enzyme molecule. Acrylamide aldo-keto reductase family 1 member A1 Homo sapiens