Title : Prostacyclin mediates the potentiated hypotensive effect of bradykinin following captopril treatment.

Pub. Date : 1980 Sep 5

PMID : 6998710






3 Functional Relationships(s)
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1 Prostacyclin mediates the potentiated hypotensive effect of bradykinin following captopril treatment. Epoprostenol kininogen 1 Homo sapiens
2 The effect of angiotensin-converting enzyme inhibition by captopril on the release of a prostacyclin-like substance by bradykinin, angiotensin I and angiotensin II was studied by means of the blood-bathed bioassay technique of Vane. Epoprostenol kininogen 1 Homo sapiens
3 Potentiation of the bradykinin-induced renal vasodilatation with captopril could be completely reversed by indomethacin, which also abolished the kinin-induced release of prostacyclin-like substance. Epoprostenol kininogen 1 Homo sapiens