Title : Tumor promoter modulation of epidermal growth factor- and nerve growth factor-induced adhesion and growth factor binding of PC-12 pheochromocytoma cells.

Pub. Date : 1980 Nov

PMID : 6970201






4 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Tetradecanoyl-phorbol-acetate (TPA), a potent tumor promoter, blocks the EGF-induced increase in adhesion rate of PC-12 cells, but does not alter the NGF-induced increase in adhesion rate. Tetradecanoylphorbol Acetate epidermal growth factor like 1 Rattus norvegicus
2 Tetradecanoyl-phorbol-acetate (TPA), a potent tumor promoter, blocks the EGF-induced increase in adhesion rate of PC-12 cells, but does not alter the NGF-induced increase in adhesion rate. Tetradecanoylphorbol Acetate epidermal growth factor like 1 Rattus norvegicus
3 TPA shifts the EGF bindings curve to the right for PC-12 cells, but does not alter maximal EGF binding at saturating concentrations of EGF. Tetradecanoylphorbol Acetate epidermal growth factor like 1 Rattus norvegicus
4 TPA blocks the decrease in the number of short microvilli in EGF-treated cells, but not in NGF-treated cells. Tetradecanoylphorbol Acetate epidermal growth factor like 1 Rattus norvegicus