Title : Enhancement of lipid peroxidation in rat liver on acute exposure to styrene and acrylamide a consequence of glutathione depletion.

Pub. Date : 1983 Aug 1

PMID : 6883577






3 Functional Relationships(s)
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1 In liver both acrylamide and styrene caused an increase in lipid peroxidation and decrease in glutathione contents and activity of glutathione-S-transferase in a dose dependent manner, while in brain only acrylamide produced a decrease in glutathione content. Acrylamide hematopoietic prostaglandin D synthase Rattus norvegicus
2 In liver both acrylamide and styrene caused an increase in lipid peroxidation and decrease in glutathione contents and activity of glutathione-S-transferase in a dose dependent manner, while in brain only acrylamide produced a decrease in glutathione content. Acrylamide hematopoietic prostaglandin D synthase Rattus norvegicus
3 The inhibition of glutathione-S-transferase activity by acrylamide and styrene suggests that detoxication of these neurotoxic compounds could be suppressed following acute exposure. Acrylamide hematopoietic prostaglandin D synthase Rattus norvegicus