Title : Effects of methylcholanthrene and benzanthracene on blastogenesis and aryl hydrocarbon hydroxylase induction in splenic lymphocytes from three inbred strains of mice.

Pub. Date : 1983

PMID : 6874165






3 Functional Relationships(s)
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1 In mitogen-activated and non-activated lymphocytes from C57BL and C3H mice (AHH responsive strains) the percentage of blastogenesis induced by BA or MCA was higher than in lymphocytes from the non-responsive strain (DBA/2). benz(a)anthracene cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus
2 On the basis of the PAH concentrations used MCA and BA were similar as inducers of blastogenesis and of AHH activity. benz(a)anthracene cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus
3 In responsive strains, 10 microM oF BA or 1.5 microM of MCA induced AHH 2-5 fold, while in non-responsive mice induced AHH was very close to the basal level. benz(a)anthracene cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus