Title : Oxygen-18 leaving group kinetic isotope effects on the hydrolysis of nitrophenyl glycosides. 2. Lysozyme and beta-glucosidase: acid and alkaline hydrolysis.

Pub. Date : 1981 May 26

PMID : 6788083






1 Functional Relationships(s)
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1 The large magnitude of these KIEs requires that carbon-oxygen bond scission be far advanced in the transition states for these reactions; therefore in the transition states for the first irreversible steps in these reaction sequences, scission of the glycosidic bond must be essentially complete for the reactions catalyzed by lysozyme and beta-glucosidase A, which are thought to proceed via SN1 and SN2 mechanisms, respectively. Oxygen solute carrier family 38 member 5 Homo sapiens