Title : Studies on adrenal phenylethanolamine N- methyltransferase (PNMT) with S K & F 64139, a selective inhibitor.

Pub. Date : 1976 Jun

PMID : 6786






1 Functional Relationships(s)
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1 SK&F 64139 is a potent, reversible inhibitor of phenylethanolamine N-methyltransferase; its IC50 concentration in our standard assay system was 1 X 10(-7) M. Kinetically, the compound is a competitive inhibitor with respect to norepinephrine but is uncompetitive when S-adenosylmethionine is the variable substrate. Norepinephrine phenylethanolamine-N-methyltransferase Rattus norvegicus