Title : The role of intermolecular disulfide bonding in deposition of GP140 in the extracellular matrix.

Pub. Date : 1984 Jul

PMID : 6736123






2 Functional Relationships(s)
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1 Analysis of the sequence of events in assembly of GP140 and fibronectin in the extracellular matrix detected the following: (a) fibronectin was first to appear in the extracellular matrix; (b) GP140 accumulated in the cytoplasm, then deposited in the extracellular matrix and co-aligned with the established fibronectin; and (c) maturation of the extracellular matrix proceeded by continued intermolecular disulfide bonding. Disulfides fibronectin 1 Homo sapiens
2 Precipitation of the biotinylated matrix from extracts of the cultures using avidin indicated: (a) disulfide bonding of radioactive GP140 and fibronectin into the exogenous biotinylated matrix required cell contact with the matrix. Disulfides fibronectin 1 Homo sapiens