Pub. Date : 1984 Mar
PMID : 6732356
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effect of verapamil on the decrease in renal blood flow (RBF) induced by angiotensin II (Ang II), norepinephrine (NE) or renal nerve stimulation (RNS) was examined in pentobarbital-anesthetized dogs. | Verapamil | ANG | Canis lupus familiaris |
| 2 | The renal arterial infusion of verapamil (30 micrograms/min followed by 100 micrograms/min) brought about a sustained increase in RBF and inhibition of renal vasoconstriction induced by Ang II or NE, but not by RNS, when the extent of vasoconstriction was estimated in terms of absolute changes in RBF. | Verapamil | ANG | Canis lupus familiaris |
| 3 | We also observed that the inhibitory effect of verapamil on Ang II-induced vasoconstriction was greater than on NE-induced constriction, as estimated from the % change in RBF. | Verapamil | ANG | Canis lupus familiaris |
| 4 | These results indicate that in canine renal vasculature, verapamil exerts different inhibitory effects on the vasoconstriction induced by Ang II, NE or RNS. | Verapamil | ANG | Canis lupus familiaris |