Title : Effects of maternal hyperphenylalaninemia on fetal brain development: a morphological study.

Pub. Date : 1983 Mar

PMID : 6681776






1 Functional Relationships(s)
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1 High concentrations of phenylalanine were induced in pregnant rats from embryonic days 14 through 21 by subcutaneous injections of alpha-methylphenylalanine (mPhe) (to inhibit maternal phenylalanine hydroxylase) at a dosage of 30 mg/100 g body weight plus phenylalanine (Phe) supplementation (to raise fetal plasma phenylalanine) at a dosage of 60 mg/100 g body weight two times daily at 12-h intervals. Phenylalanine phenylalanine hydroxylase Rattus norvegicus