Title : Binding of fibronectin and its proteolytic fragments to glycosaminoglycans. Exposure of cryptic glycosaminoglycan-binding domains upon limited proteolysis.

Pub. Date : 1983 Dec 10

PMID : 6643486






4 Functional Relationships(s)
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1 Binding of intact plasma fibronectin and its proteolytic fragments to glycosaminoglycans immobilized on agarose beads was systematically compared at different ionic strengths. Glycosaminoglycans fibronectin 1 Homo sapiens
2 Fractionation of the thermolysin digest of fibronectin on the glycosaminoglycan-Sepharoses at low ionic strength revealed that three groups of fragments, i.e. Mr = 150,000-140,000, 24,000, and 16,000 (150K-140K, 24K, and 16K) fragments, were capable of binding to glycosaminoglycans with different specificities and affinities. Glycosaminoglycans fibronectin 1 Homo sapiens
3 Fractionation of the thermolysin digest of fibronectin on the glycosaminoglycan-Sepharoses at low ionic strength revealed that three groups of fragments, i.e. Mr = 150,000-140,000, 24,000, and 16,000 (150K-140K, 24K, and 16K) fragments, were capable of binding to glycosaminoglycans with different specificities and affinities. Glycosaminoglycans fibronectin 1 Homo sapiens
4 The binding of fibronectin and its fragments to glycosaminoglycans is dependent on the ionic strength. Glycosaminoglycans fibronectin 1 Homo sapiens