Title : Suicide inactivation of rat liver cytochrome P-450 by chloramphenicol in vivo and in vitro.

Pub. Date : 1983 Mar

PMID : 6601233






1 Functional Relationships(s)
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1 Both the endogenous NADPH oxidase activity and the enzymatic reduction of cytochrome P-450 are inhibited by chloramphenicol treatment, whereas the Km and Ks for ethoxycoumarin and the cumene hydroperoxide- or iodosobenzene-supported deethylation of ethoxycoumarin are unaffected, suggesting that impaired electron transport to cytochrome P-450 may be the cause of the loss of enzymatic activity. Potassium cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus