Title : Strong evidence from studies with brachymorphic mice and pentachlorophenol that 1'-sulfoöxysafrole is the major ultimate electrophilic and carcinogenic metabolite of 1'-hydroxysafrole in mouse liver.

Pub. Date : 1983 Nov

PMID : 6577945






1 Functional Relationships(s)
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1 Likewise, the chronic administration of a nontoxic level of pentachlorophenol in the diet of adult female CD-1 mice strongly inhibited hepatic tumor induction by long-term dietary administration of either safrole or 1"-hydroxysafrole. 1'-hydroxysafrole CD1 antigen complex Mus musculus