Title : Effect of seneciphylline and senecionine on hepatic drug metabolizing enzymes in rats.

Pub. Date : 1984 Dec

PMID : 6533413






2 Functional Relationships(s)
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1 The effect of oral administration of the pyrrolizidine alkaloids, seneciphylline and senecionine, from Senecio vulgaris (Compositae) on activities of hepatic epoxide hydrase, glutathione-S-transferase, aminopyrine-N-demethylase and arylhydrocarbon hydroxylase (AHH) was investigated in microsomes of young male albino rats. seneciphylline hematopoietic prostaglandin D synthase Rattus norvegicus
2 Seneciphylline significantly increased the activities of epoxide hydrase and glutathione-S-transferase but caused reduction of cytochrome P-450 and related monooxygenase activities. seneciphylline hematopoietic prostaglandin D synthase Rattus norvegicus