Title : Chlorinated paraffins: effect of some microsomal enzyme inducers and inhibitors on the degradation of 1-14C-chlorododecanes to 14CO2 in mice.

Pub. Date : 1984 Aug

PMID : 6437140






1 Functional Relationships(s)
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1 Pretreatment with cytochrome P-450 inhibitors resulted in a marked decrease in the rate of 14CO2-formation, when measured as peak 14CO2-exhalation rate (PER): After piperonyl butoxide pretreatment the degradation rate of a high-chlorinated 14C-dodecane (PCDD II; 68% Cl w/w) to 14CO2 was 16% of control, and after metyrapone pretreatment 40%. Piperonyl Butoxide cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus