Title : Blood coagulation and acute iron toxicity. Reversible iron-induced inactivation of serine proteases in vitro.

Pub. Date : 1984 Apr

PMID : 6421970






1 Functional Relationships(s)
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1 Because the amidolytic activity of human thrombin as well as factor Xa, kallikrein, and bovine trypsin was also reversibly suppressed by ferrous sulfate as well as ferric citrate, we consider it likely that the coagulopathy occurring in iron poisoning is the consequence of a general, physiologically important phenomenon: the susceptibility of serine proteases to nontransferrin-bound Fe3+. ferric citrate coagulation factor X Homo sapiens