Pub. Date : 1984 Mar
PMID : 6321134
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To assess the relevance of the class of TSH-binding sites characterized by low affinity and high capacity to the stimulation of adenylate cyclase, we studied the interactions of desialylated hCG (as-hCG) and its beta-subunit (as-hCG beta) with human thyroid membranes. | Thyrotropin | chorionic gonadotropin subunit beta 5 | Homo sapiens |
| 2 | To assess the relevance of the class of TSH-binding sites characterized by low affinity and high capacity to the stimulation of adenylate cyclase, we studied the interactions of desialylated hCG (as-hCG) and its beta-subunit (as-hCG beta) with human thyroid membranes. | Thyrotropin | chorionic gonadotropin subunit beta 5 | Homo sapiens |
| 3 | In low ionic strength buffer, pH 7.8, where both classes of sites are operant, as-hCG fully inhibited and as-hCG beta partially inhibited [125I] bovine (b) TSH binding. | Thyrotropin | chorionic gonadotropin subunit beta 5 | Homo sapiens |
| 4 | In contrast, the as-hCG molecule, which interacts with both classes of TSH-binding sites, fully inhibited TSH stimulation of adenylate cyclase. | Thyrotropin | chorionic gonadotropin subunit beta 5 | Homo sapiens |
| 5 | In contrast, the as-hCG molecule, which interacts with both classes of TSH-binding sites, fully inhibited TSH stimulation of adenylate cyclase. | Thyrotropin | chorionic gonadotropin subunit beta 5 | Homo sapiens |