Title : Lead and other metals can substitute for Ca2+ in calmodulin.

Pub. Date : 1983 Sep

PMID : 6314931






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Calmodulin dependent phosphodiesterase was activated with Pb2+, Ca2+, Sr2+, Ba2+, and Cd2+ (EC50 about 0.8 microM). strontium cation calmodulin 1 Homo sapiens
2 Calmodulin binding to brain membranes was enhanced with concentrations below 10(-4)M in the following order: Pb2+ greater than or equal to Ca2+ approximately Sr2+ greater than Cd2+ greater than Mn2+ greater than Ba2+. strontium cation calmodulin 1 Homo sapiens
3 In the flow-dialysis, other ions competed with 45Ca2+ binding to calmodulin in the following order: Pb2+ approximately Ca2+ greater than Mn2+, Ba2+, Cd2+, Sr2+. strontium cation calmodulin 1 Homo sapiens