Pub. Date : 1981 Jul
PMID : 6269043
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The role of prostaglandins in the renin release response to renal nerve stimulation (RNS) at different intensities was examined in the anaesthetized dog. | Reactive Nitrogen Species | renin | Canis lupus familiaris |
| 2 | ), prostaglandin synthesis inhibitors, did not affect the renin release response to low level RNS but decreased the renin release response to high level RNS by 31 +/- 8% (P less than 0.01). | Reactive Nitrogen Species | renin | Canis lupus familiaris |
| 3 | beta-1-adrenoceptor antagonist, to indomethacin or diclofenac sodium resulted in a greater reduction (68 +/- 6% P less than 0.01) of the renin release response to high level RNS compared to that produced by either drug alone. | Reactive Nitrogen Species | renin | Canis lupus familiaris |
| 4 | Metoprolol, alone, reduced the renin release response to high level RNS by 37 +/- 14% (P less than 0.05). | Reactive Nitrogen Species | renin | Canis lupus familiaris |
| 5 | Addition of metoprolol to phenoxybenzamine practically abolished the renal vasoconstrictor response and the renin release response to high level RNS; 94 +/- 4% (P less than 0.01). | Reactive Nitrogen Species | renin | Canis lupus familiaris |
| 6 | These findings suggest that low level RNS results in renin release which is not dependent on prostaglandins. | Reactive Nitrogen Species | renin | Canis lupus familiaris |
| 7 | High level RNS results in renin release which is partly mediated by beta-1-adrenoceptors and partly related to alpha-adrenoceptors mediated renal vasoconstriction. | Reactive Nitrogen Species | renin | Canis lupus familiaris |