Pub. Date : 1981 Summer
PMID : 6268397
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Presumably, the action of ACTH causes an increase in the activity of cholesterol side chain cleavage, the rate-limiting step in the conversion of cholesterol to steroid hormones. | Cholesterol | proopiomelanocortin | Homo sapiens |
| 2 | Presumably, the action of ACTH causes an increase in the activity of cholesterol side chain cleavage, the rate-limiting step in the conversion of cholesterol to steroid hormones. | Cholesterol | proopiomelanocortin | Homo sapiens |
| 3 | We suggest that once the mitochondrial cholesterol side-chain cleavage system is fully activated by ACTH, the supply of cholesterol to the mitochondria becomes rate-limiting for steroidogenesis. | Cholesterol | proopiomelanocortin | Homo sapiens |
| 4 | We suggest that once the mitochondrial cholesterol side-chain cleavage system is fully activated by ACTH, the supply of cholesterol to the mitochondria becomes rate-limiting for steroidogenesis. | Cholesterol | proopiomelanocortin | Homo sapiens |
| 5 | To meet this demand for cholesterol, a further action of ACTH results in an increase in the number of LDL receptors. | Cholesterol | proopiomelanocortin | Homo sapiens |
| 6 | In addition, ACTH stimulates the activity of HMG CoA reductase and, thus, the rate of de novo cholesterol biosynthesis. | Cholesterol | proopiomelanocortin | Homo sapiens |