Pub. Date : 1980 Aug
PMID : 6248808
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sites at which clonidine acts to affect blood pressure and the secretion of renin, growth hormone and ACTH. | Clonidine | somatotropin | Canis lupus familiaris |
| 2 | To further define the sites in the brain at which clonidine acts to lower blood pressure, inhibit renin secretion, inhibit ACTH secretion, and stimulate growth hormone secretion, small doses of this drug were infused into the vertebral arteries, into the carotid arteries and intravenously in pentobarbital-anesthetized dogs. | Clonidine | somatotropin | Canis lupus familiaris |
| 3 | Intracarotid clonidine, 2 microgram/kg, decreased plasma ACTH and corticoids and increased plasma growth hormone, whereas the same dose had no effect on these hormones when given intravenously or when given intravertebrally after occlusion of the basilar artery. | Clonidine | somatotropin | Canis lupus familiaris |
| 4 | The data support the conclusion that clonidine acts rostral to the pons to decrease ACTH secretion and increase growth hormone secretion, whereas it acts on the medulla or adjacent hindbrain to lower blood pressure. | Clonidine | somatotropin | Canis lupus familiaris |