Pub. Date : 1984 Fall
PMID : 6209349
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The mechanism by which NDV, Sindbis virus, and VSV enter "aged" primary chick embryo cells to initiate IFN induction was studied by using NH4Cl, a lysosomotropic weak base that compromises low pH-dependent membrane fusion. | Ammonium Chloride | interferon alpha 1 | Homo sapiens |
| 2 | NH4Cl was used to perturb the early steps in virus entry into the cytosol thought to result ultimately in presentation of dsRNA to the cell"s first-stage recognition system for IFN induction. | Ammonium Chloride | interferon alpha 1 | Homo sapiens |
| 3 | Sindbis virus infectivity and IFN-inducing particle activity were inhibited similarly in an NH4Cl concentration-dependent manner. | Ammonium Chloride | interferon alpha 1 | Homo sapiens |
| 4 | While the infectivity of VSV was very sensitive to the action of NH4Cl, virtually all IFN-inducing particles were functional; however, the quantum yield of IFN they induced was reduced in an NH4Cl concentration-dependent manner. | Ammonium Chloride | interferon alpha 1 | Homo sapiens |
| 5 | While the infectivity of VSV was very sensitive to the action of NH4Cl, virtually all IFN-inducing particles were functional; however, the quantum yield of IFN they induced was reduced in an NH4Cl concentration-dependent manner. | Ammonium Chloride | interferon alpha 1 | Homo sapiens |
| 6 | Infectivity and IFN induction by Sindbis virus and VSV share a common, limiting step in NH4Cl treated cells: transfer of viral RNA from basic vacuoles into the cell cytosol. | Ammonium Chloride | interferon alpha 1 | Homo sapiens |