Title : Dexamethasone inhibition of rat hepatoma growth and alpha-fetoprotein synthesis.

Pub. Date : 1984 Jul

PMID : 6202403






4 Functional Relationships(s)
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1 Treatment of rats with dexamethasone strongly reduced (by 83 to 98%) the serum levels of AFP in rats bearing Morris hepatomas 7777, 8994, 7288c , and 9618A2 . Dexamethasone alpha-fetoprotein Rattus norvegicus
2 Reduced AFP levels were due in part to a large reduction in tumor load in dexamethasone-treated rats. Dexamethasone alpha-fetoprotein Rattus norvegicus
3 RNA dot hybridization also indicated that dexamethasone reduced the amount of AFP mRNA in hepatoma 7777 while increasing albumin mRNA. Dexamethasone alpha-fetoprotein Rattus norvegicus
4 Two-dimensional gel electrophoresis of tumor cytosol proteins showed that dexamethasone reduced synthesis of all AFP variants which could be detected by this technique. Dexamethasone alpha-fetoprotein Rattus norvegicus