Title : Anticoagulant and antiheparin activities of a pentosan polysulphate.

Pub. Date : 1983 Jul 1

PMID : 6193602






4 Functional Relationships(s)
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Protein Name
Organism
1 Pentosan polysulphate (PPS, Hemoclar, MW 6,700) was observed to have a low affinity for ATIII-Sepharose eluting at 0.3M NaCl. Pentosan Sulfuric Polyester serpin family C member 1 Homo sapiens
2 Pentosan polysulphate (PPS, Hemoclar, MW 6,700) was observed to have a low affinity for ATIII-Sepharose eluting at 0.3M NaCl. Pentosan Sulfuric Polyester serpin family C member 1 Homo sapiens
3 The antiheparin effect of PPS was also observed in a purified system in obviating the heparin potentiation of the rate of inhibition of thrombin by antithrombin III. Pentosan Sulfuric Polyester serpin family C member 1 Homo sapiens
4 Observations showed that at higher concentrations of PPS it acted by directly inhibiting thrombin without the intervention of antithrombin III but also to potentiate the rate of fibrin monomer polymerization. Pentosan Sulfuric Polyester serpin family C member 1 Homo sapiens