Pub. Date : 1983 Sep
PMID : 6193139
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Purified porcine insulin significantly augmented the biosynthesis and secretion of progesterone by cultured granulosa cells. | Progesterone | insulin | Sus scrofa |
| 2 | Under serum-restricted conditions, insulin also significantly amplified the capacity of estradiol and 8-bromo cyclic AMP to stimulate progesterone production. | Progesterone | insulin | Sus scrofa |
| 3 | The stimulation of progesterone production by insulin was attributable to increased biosynthesis of pregnenolone, rather than diminished catabolism of progesterone to its principal metabolite, 20alpha-hydroxypregn-4-en-3-one. | Progesterone | insulin | Sus scrofa |
| 4 | Insulin also enhanced progesterone production in the presence of a soluble sterol substrate, 5-cholesten-3beta,25-diol, which readily gains access to the mitochondrial cholesterol side-chain cleavage system. | Progesterone | insulin | Sus scrofa |
| 5 | Insulin"s augmentation of progesterone production reflected a selective action on progestin biosynthesis, since insulin significantly suppressed estrogen biosynthesis by granulosa cells.Thus, our investigations indicate that insulin acts on ovarian cells selectively to stimulate pregnenolone (but not estrogen) biosynthesis. | Progesterone | insulin | Sus scrofa |
| 6 | Insulin"s augmentation of progesterone production reflected a selective action on progestin biosynthesis, since insulin significantly suppressed estrogen biosynthesis by granulosa cells.Thus, our investigations indicate that insulin acts on ovarian cells selectively to stimulate pregnenolone (but not estrogen) biosynthesis. | Progesterone | insulin | Sus scrofa |