Title : The effect of calmodulin antagonists on amylase release from the rat parotid gland in vitro.

Pub. Date : 1983 May

PMID : 6192391






2 Functional Relationships(s)
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1 A different calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, partially inhibited release while 8-(N,N-diethylamino)-octyl 3,4,5-trimethoxybenzoate hydrochloride (TMB-8) completely blocked the amylase release induced by the cyclic AMP derivative. 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate calmodulin 1 Rattus norvegicus
2 However, concentrations of TMB-8 inhibiting amylase release drastically reduced the ATP concentration of rat parotid minces, suggesting that the inhibition of secretion was due to toxic effects of TMB-8 on parotid cells rather than the ability of the compound to antagonize calmodulin. 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate calmodulin 1 Rattus norvegicus