Title : Hapten-specific responses to the phenyltrimethylamino hapten. IV. Occurrence of mechanistically distinct idiotypic suppressor T cells before the appearance of anti-idiotypic suppressor T cells induced by the monovalent antigen L-tyrosine-p-azophenyltrimethylammonium.

Pub. Date : 1983 Jun

PMID : 6189892






3 Functional Relationships(s)
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1 injection of the monovalent synthetic antigen, L-tyrosine-p-azophenyltrimethylammonium [tyr(TMA)] in complete Freund"s adjuvant induces an anti-idiotypic T suppressor cell (Ts2) population that can be detected 6 wk later by its ability to shut down delayed-type hypersensitivity (DTH) specific for the TMA hapten. 4,4-dimethylcholesta-8,14-dien-3-ol Trichinella spiralis resistance 2 Mus musculus
2 This latter point is in marked contrast to our previous observation that the tyr(TMA)-induced anti-idiotypic Ts2 fail to function intrinsically and can only be detected upon adoptive transfer into naive mice. 4,4-dimethylcholesta-8,14-dien-3-ol Trichinella spiralis resistance 2 Mus musculus
3 Finally, we show that when Ts1-bearing mice are primed and boosted for anti-TMA antibody formation, the resulting response was overall reduced with respect to the idiotype-positive and negative plaque-forming cells that differs from the Ts2-bearing hosts wherein the idiotypic component is preferentially suppressed. 4,4-dimethylcholesta-8,14-dien-3-ol Trichinella spiralis resistance 2 Mus musculus