Title : The effects of intracerebroventricular administration of tonin on water drinking and blood pressure in rats.

Pub. Date : 1980 Oct

PMID : 6165574






3 Functional Relationships(s)
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1 The effects of intracerebroventricular administration of tonin on water drinking and blood pressure in rats. Water kallikrein 1-related peptidase C2 Rattus norvegicus
2 Intraventricular administration of tonin, an enzyme which forms angiotensin II directly from a natural protein substrate (angiotensinogen), stimulated water drinking and increased systemic blood pressure in rats. Water kallikrein 1-related peptidase C2 Rattus norvegicus
3 These results indicate that the central effects of tonin on water drinking and systemic blood pressure are mediated via the direct formation of angiotensin II in the brain, and suggest the possibility that the tonin-angiotensin II system in the central nervous system might be important in controlling water balance and blood pressure. Water kallikrein 1-related peptidase C2 Rattus norvegicus