Title : [Synthesis and H2-antihistaminic effect of N,N'-bisheteroaryl N,N'-bisheteroaryl-substituted cyanoguanidines and 2-nitro-1,1-ethenediamines. 17. H2-antihistaminics].

Pub. Date : 1984

PMID : 6149751






1 Functional Relationships(s)
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1 In studies on structure-activity relationships of histamine H2-receptor antagonists, cyanoguanidines and 2-nitro-1,1-ethendiamines, which contain the heterocyclic rings of ranitidine and cimetidine twofold, were prepared and tested for their H2-antihistaminic activity on the isolated guinea-pig atrium and on the histamine stimulated acid secretion of the anaesthetized rat. Ranitidine histamine H2 receptor Cavia porcellus