Pub. Date : 1984 Oct
PMID : 6149663
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 12-O-tetradecanoyl phorbol-13-acetate (TPA), the most potent phorbol ester, stimulated GH accumulation in the cultured medium in a dose-dependent manner. | Tetradecanoylphorbol Acetate | gonadotropin releasing hormone receptor | Rattus norvegicus |
| 2 | 12-O-tetradecanoyl phorbol-13-acetate (TPA), the most potent phorbol ester, stimulated GH accumulation in the cultured medium in a dose-dependent manner. | Tetradecanoylphorbol Acetate | gonadotropin releasing hormone receptor | Rattus norvegicus |
| 3 | A time course study indicated that TPA mainly stimulates release of GH. | Tetradecanoylphorbol Acetate | gonadotropin releasing hormone receptor | Rattus norvegicus |
| 4 | The maximal stimulation of GH release by TPA (100 ng/ml) was 3-4-fold over control. | Tetradecanoylphorbol Acetate | gonadotropin releasing hormone receptor | Rattus norvegicus |
| 5 | TPA-stimulated GH release was not affected by the presence of indomethacin, an inhibitor of prostaglandin (PG) synthesis, indicating that PG is not involved in the process of TPA-stimulated GH release. | Tetradecanoylphorbol Acetate | gonadotropin releasing hormone receptor | Rattus norvegicus |
| 6 | Co++, a competitive antagonist of Ca++, at 2.0 mM completely suppressed the GH release induced by TPA, and this inhibition was partially reversed by the addition of 2.0 mM Ca++. | Tetradecanoylphorbol Acetate | gonadotropin releasing hormone receptor | Rattus norvegicus |
| 7 | Verapamil, a Ca++ channel blocker, reduced TPA-stimulated GH release, and trifluoperazine, an inhibitor of Ca-calmodulin formation, had a similar effect. | Tetradecanoylphorbol Acetate | gonadotropin releasing hormone receptor | Rattus norvegicus |
| 8 | Somatostatin (SRIF) also inhibited the GH release by TPA. | Tetradecanoylphorbol Acetate | gonadotropin releasing hormone receptor | Rattus norvegicus |
| 9 | These observations are compatible with the idea that Ca++ may be involved in the process of TPA-stimulated GH release. | Tetradecanoylphorbol Acetate | gonadotropin releasing hormone receptor | Rattus norvegicus |