Title : Antagonistic effect of theophylline on the adenosine-induced decreased in renin release.

Pub. Date : 1984 Aug

PMID : 6087679






5 Functional Relationships(s)
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1 Antagonistic effect of theophylline on the adenosine-induced decreased in renin release. Adenosine renin Canis lupus familiaris
2 The action of theophylline on the adenosine-induced decrease in renin release was studied in anesthetized dogs. Adenosine renin Canis lupus familiaris
3 Adenosine inhibited renin release, decreased GFR and fractional sodium excretion, and decreased the concentration of angiotensin II in the renal lymph. Adenosine renin Canis lupus familiaris
4 The intrarenal infusion of adenosine (3 X 10(-7) mol/min) during theophylline infusion produced no effect on GFR or RBF, but fractional sodium excretion and renin release were significantly decreased. Adenosine renin Canis lupus familiaris
5 These findings demonstrate that theophylline, at concentrations having no effect on cortical cAMP, antagonizes the effect of adenosine on renin release. Adenosine renin Canis lupus familiaris