Title : Effects of cardiac glycosides on electrical activity in the isolated retina of the frog.

Pub. Date : 1967 Jul

PMID : 6034759






2 Functional Relationships(s)
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1 When the glycoside is placed on the receptor surface, in 7 min the ERG is completely eliminated by 10(-4)M ouabain and more than 90% inhibited by 3 x 10(-5)M ouabain. Glycosides ETS transcription factor ERG Homo sapiens
2 The evidence suggests that abolition of the ERG by ouabain is due principally to inhibition of the active transport of sodium: (a) Structurally modified glycosides which are considerably less potent inhibitors of alkali cation-activated ATPase activity in preparations of frog retinal outer segments are also poorer inhibitors of electrical activity in isolated retinas. Glycosides ETS transcription factor ERG Homo sapiens