Title : On the mechanism of lithium-induced diabetes insipidus in man and the rat.

Pub. Date : 1974 Apr

PMID : 4360856






2 Functional Relationships(s)
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1 Rats receiving lithium (3-4 meq/kg/day) developed massive polyuria that was resistant to vasopressin, in comparison to rats with comparable polyuria induced by drinking glucose. Lithium arginine vasopressin Rattus norvegicus
2 The present studies suggest that nephrogenic diabetes insipidus is a common finding after lithium treatment and results in part from interference with the mediation of vasopressin at a step distal to the formation of 3",5" cyclic AMP. Lithium arginine vasopressin Rattus norvegicus