Title : On the interaction between phenytoin and digoxin.

Pub. Date : 1985

PMID : 4054206






1 Functional Relationships(s)
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1 Coadministration of phenytoin caused a significant reduction in the elimination half-life of digoxin from 33.9 to 23.7 h and a diminution in AUC0-48 from 31.6 to 24.4 ng X ml-1 X h. Renal digoxin clearance was not significantly altered from 135.7 to 120.3 ml X min-1. Phenytoin CD59 molecule (CD59 blood group) Homo sapiens