Title : Role of 3,5-dichlorophenyl methyl sulfone, a metabolite of m-dichlorobenzene, in the induction of hepatic microsomal drug-metabolizing enzymes by m-dichlorobenzene in rats.

Pub. Date : 1985 Apr

PMID : 4035682






2 Functional Relationships(s)
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Protein Name
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1 The extent of increases in aminopyrine N-demethylase activity and in the content of cytochrome P-450 at 48 hr after po administration of 200 mg/kg (1.36 mmol/kg) of m-DCB was almost equal to that 72 hr after the ip administration of 25 mumol/kg of the sulfone (Kimura et al., 1983). Sulfones cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus
2 The sulfone showed type I interaction with the cytochrome P-450 (Ks, 0.17 mM). Sulfones cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus