Pub. Date : 1985 Feb 12
PMID : 3996466
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Clonidine can lower blood pressure by inhibiting vasopressin release. | Clonidine | arginine vasopressin | Rattus norvegicus |
| 2 | The effect of clonidine on vasopressin release was studied in chloralose anesthetized rats which were made hypertensive by bilateral electrolytic lesions of the nucleus tractus solitarii (NTS). | Clonidine | arginine vasopressin | Rattus norvegicus |
| 3 | Furthermore, the ability of a vasopressin antagonist to lower arterial pressure in NTS hypertensive rats was markedly attenuated by clonidine treatment. | Clonidine | arginine vasopressin | Rattus norvegicus |
| 4 | These data demonstrate that part of the antihypertensive effect of clonidine in NTS hypertensive rats is due to inhibition of vasopressin release into the circulation. | Clonidine | arginine vasopressin | Rattus norvegicus |