Title : Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme.

Pub. Date : 1985 May

PMID : 3995584






1 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMG CoA reductase) is a single polypeptide chain with two contiguous domains: a soluble domain (548 amino acids) that catalyzes the rate-controlling step in cholesterol synthesis and a membrane-bound domain (339 amino acids) that anchors the protein to the endoplasmic reticulum (ER). Cholesterol 3-hydroxy-3-methylglutaryl-coenzyme A reductase Cricetulus griseus