Title : Conversion of the neurotoxic precursor 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine into its pyridinium metabolite by human platelet monoamine oxidase type B.

Pub. Date : 1985 Jun 24

PMID : 3875815






2 Functional Relationships(s)
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1 We now report that [3H]MPTP is rapidly converted in vitro into [3H]MPP+ by human platelet MAO-B. 3-hydroxy-1-methyl-3-phenyl-2-piperidinone monoamine oxidase B Homo sapiens
2 The formation of [3H]MPP+ in human platelets is prevented by specific MAO-B but not by MAO-A or by 5-hydroxytryptamine uptake inhibitors. 3-hydroxy-1-methyl-3-phenyl-2-piperidinone monoamine oxidase B Homo sapiens