Title : A comparative study on the effects of disulfiram and beta-lactam antibiotics on the acetaldehyde-metabolizing system in rats.

Pub. Date : 1986 Nov

PMID : 3820856






4 Functional Relationships(s)
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1 These effects were compared those with disulfiram, well-known as a potent inhibitor of aldehyde dehydrogenase (ALDH). Disulfiram aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus
2 These effects were compared those with disulfiram, well-known as a potent inhibitor of aldehyde dehydrogenase (ALDH). Disulfiram aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus
3 Both disulfiram and antibiotics containing the N-methyltetrazolylthiomethyl group inhibited both mitochondrial low Km ALDH and acetaldehyde oxidation in rat livers. Disulfiram aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus
4 When ethanol was given to rats pretreated with disulfiram or these antibiotics, the blood acetaldehyde concentration increased markedly concomitant with a decrease in activity of the low Km ALDH. Disulfiram aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus