Title : Glucagon and vasopressin interactions on Ca2+ movements in isolated hepatocytes.

Pub. Date : 1986 Aug 1

PMID : 3800909






5 Functional Relationships(s)
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1 Preincubating the cells with a low concentration of glucagon (0.1 nM) for 2 min markedly accelerated the fast phase and elevated the plateau of the [Ca2+]i increase caused by vasopressin. Glucagon arginine vasopressin Rattus norvegicus
2 Preincubating the cells with 0.1 nM-glucagon accelerated the rate of the fast phase of the [Ca2+]i rise caused by the subsequent addition of vasopressin. Glucagon arginine vasopressin Rattus norvegicus
3 In the absence of external free Ca2+, higher concentrations (1 nM-0.1 microM) of glucagon, which initiated larger increases in [Ca2+]i, drastically decreased the subsequent Ca2+ response to vasopressin (10 nM). Glucagon arginine vasopressin Rattus norvegicus
4 It is suggested that, in the liver, glucagon accelerates the fast phase and elevates the plateau of the vasopressin-mediated [Ca2+]i increase respectively by releasing Ca2+ from the same internal store as that permeabilized by vasopressin, probably the endoplasmic reticulum, and potentiating the influx of extracellular Ca2+ caused by this hormone. Glucagon arginine vasopressin Rattus norvegicus
5 It is suggested that, in the liver, glucagon accelerates the fast phase and elevates the plateau of the vasopressin-mediated [Ca2+]i increase respectively by releasing Ca2+ from the same internal store as that permeabilized by vasopressin, probably the endoplasmic reticulum, and potentiating the influx of extracellular Ca2+ caused by this hormone. Glucagon arginine vasopressin Rattus norvegicus