Title : Cholecystokinin antagonizes morphine induced hypoactivity and hyperactivity in hamsters.

Pub. Date : 1986 Nov

PMID : 3786358






3 Functional Relationships(s)
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1 Three experimental replications were used to test the effects of three doses (25, 50 or 75 micrograms/kg) of cholecystokinin octapeptide (CCK-8) on morphine induced changes in activity. Morphine cholecystokinin Mesocricetus auratus
2 Results indicated that a 25 micrograms/kg dose of CCK-8 blocked the hypoactivity elicited by morphine 40-60 min after opiate injection, whereas a 75 micrograms/kg dose of CCK-8 blocked the hyperactivity elicited by morphine 80-100 min after opiate injection. Morphine cholecystokinin Mesocricetus auratus
3 Results indicated that a 25 micrograms/kg dose of CCK-8 blocked the hypoactivity elicited by morphine 40-60 min after opiate injection, whereas a 75 micrograms/kg dose of CCK-8 blocked the hyperactivity elicited by morphine 80-100 min after opiate injection. Morphine cholecystokinin Mesocricetus auratus