Title : Differential effects of pre- and posttreatment of sodium arsenite on the genotoxicity of methyl methanesulfonate in Chinese hamster ovary cells.

Pub. Date : 1986 Apr

PMID : 3753897






2 Functional Relationships(s)
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1 Pretreatment of sodium arsenite reduces hypoxanthine-guanine phosphoribosyltransferase mutagenicity and overcomes the inhibition of mitosis and cell proliferation but has no apparent effect on the cytotoxicity and clastogenicity in methyl methanesulfonate (MMS)-treated Chinese hamster ovary cells. sodium arsenite hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus
2 Posttreatment of sodium arsenite drastically increases the cytotoxicity, clastogenicity, hypoxanthine-guanine phosphoribosyltransferase mutagenicity, and inhibition of mitosis and cell proliferation induced by MMS. sodium arsenite hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus