Title : Steroid-binding site of human and rabbit sex steroid binding protein of plasma: fluorescence characterization with equilenin.

Pub. Date : 1986 May 6

PMID : 3718973






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The interaction of the estrogen d-3-hydroxy-1,3,5(10),6,8-estrapentaen-17-one (equilenin) with the human and rabbit sex steroid binding proteins (hSBP and rSBP, respectively) has been investigated by using fluorescence and absorption spectroscopy. Steroids selenium binding protein 1 Homo sapiens
2 The fluorescence emission of the SBP-equilenin complexes, however, exhibits wavelength shifts (red shifts) opposite to those of the steroid in low-dielectric solvents or complexed with beta-cyclodextrin (blue shifts) but similar to the red shift produced by addition of the proton acceptor triethylamine to equilenin in cyclohexane. Steroids selenium binding protein 1 Homo sapiens
3 These data indicate that the steroid-binding site of hSBP and rSBP is a nonpolar cavity containing a proton acceptor that participates in a specific interaction, possibly a hydrogen bond, with the 3"-hydroxyl group of the bound steroid. Steroids selenium binding protein 1 Homo sapiens
4 These data indicate that the steroid-binding site of hSBP and rSBP is a nonpolar cavity containing a proton acceptor that participates in a specific interaction, possibly a hydrogen bond, with the 3"-hydroxyl group of the bound steroid. Steroids selenium binding protein 1 Homo sapiens