Title : Tumor-promoting activity of benzodiazepine tranquilizers, diazepam and oxazepam, in mouse liver.

Pub. Date : 1986 May

PMID : 3698206






1 Functional Relationships(s)
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1 Both diazepam and oxazepam induced hepatomegaly, cytochrome P-450 and cytochrome P-450-dependent aminopyrine N-demethylase activity in hepatocytes, effects similar to those produced by a well-known rodent liver tumor promoter, phenobarbital. Diazepam cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus