Title : Influence of stereochemistry of the sequence Arg-Gly-Asp-Xaa on binding specificity in cell adhesion.

Pub. Date : 1987 Dec 25

PMID : 3693352






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Replacement of L-Ser with D-Ser drastically reduced the influence that the resulting peptide had on the vitronectin interaction, but this peptide showed little difference in its effect on the binding of cells to fibronectin when compared with the prototype peptide. Serine vitronectin Homo sapiens
2 Furthermore, substitution of the Ser with L-Asn resulted in a peptide that had an apparent increased preference for the fibronectin receptor and decreased preference for the vitronectin receptor. Serine vitronectin Homo sapiens